CXII.—The condensation of amides with esters of acetylenic acids
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چکیده
منابع مشابه
Addition of Zinc Homoenolates to Acetylenic Esters and Amides : A Formal [ 3 + 21 Cycloaddition
The copper-catalyzed conjugate addition-cycloacylation reaction of zinc homoenolatee with acetylenic esters or acetylenic amides is described. The zinc homoenolate is prepared from [ (ethoxycyclopropy1)oxyltrimethylsilane and zinc chloride in ether. Addition of an acetylenic amide or ester provides 2-carboxamidoor 2-carboalkoxy-3-alkylcyclopent-2-en-l-ones ingood to excellent yields. The reacti...
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Hydrothermal pyrolysis experiments were performed to assess condensation (dehydration) reactions to amide, ester, and nitrile functionalities from lipid precursors. Beside product formation, organic compound alteration and stability were also evaluated. Mixtures of nonadecanoic acid, hexadecanedioic acid, or hexadecanamide with water, ammonium bicarbonate, and oxalic acid were heated at 300 deg...
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Methods for the synthesis of esters and amides of edeine A were developed and a number of derivatives of this type was obtained and characterized. The antimicrobial activities of the derivatives are comparable to the activity of the native antibiotic and indicate that the presence of free carboxyl group in edeine is not essential for its biological assay.
متن کاملPeptides, amides, and esters of chlorethylamino derivatives of amino acids and of phenylalkancarboxylic acids: a new class of antitumor compounds.
The first stage of these studies consisted in the development of antitumor drugs of the type of alkylating metabolites 1952-55 (5, 6, 13). These are metabolites or other natural or biologically active compounds which are combined with a cytotoxic group (e.g., the chloroethylamino group). Sarcolysin and dopan are representative of drugs of this type. In the former, the essential amino acid, phen...
متن کاملBorate esters as convenient reagents for direct amidation of carboxylic acids and transamidation of primary amides.
Simple borates serve as effective promoters for amide bond formation with a variety of carboxylic acids and amines. With trimethyl or tris(2,2,2-trifluoroethyl) borate, amides are obtained in good to excellent yield and high purity after a simple work-up procedure. Tris(2,2,2-trifluoroethyl) borate can also be used for the straightforward conversion of primary amides to secondary amides via tra...
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ژورنال
عنوان ژورنال: J. Chem. Soc., Trans.
سال: 1909
ISSN: 0368-1645
DOI: 10.1039/ct9099500984